Intracerebral hemorrhage / Cerebral amyloid angiopathy
Conditions
Interventions
Probable CAA Group, Deep Intracerebral Hemorrhage Group and Healthy Group:Nil
Sponsors
Tongji Hospital Affiliated to Huazhong University of science and technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: In a single center retrospective study, patients with cerebral hemorrhage from 2013 to 2018 in the Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of science and technology were retrospectively screened for patients with probable CAA. 1. Most likely CAA: aged > 55 years; symptoms and signs of focal neurological deficit; amyloid deposition confirmed by biopsy of cortex and leptomeningeal or confirmed by CT / MRI, that is, multiple (micro) hemorrhage in cortex or subcortical (cerebellar hemorrhage may occur) or single lobe, cortex and subcortical hemorrhage + focal / disseminated surface hemosiderin deposition; 2. Patients of the same age with hypertension and deep cerebral hemorrhage were selected as the first control group; 3. Healthy old people of the same age served as the second control group; 4. Informed consent of the patient and / or authorized relatives.
Exclusion criteria
Exclusion criteria: 1. Patients with coagulation dysfunction at the time of onset or using anticoagulants before onset (INR > 1.5); 2. Patients with platelet count < 100 x 10 ^ 9 / L; 3. Patients with severe failure of other systems or final stage of various diseases; 4. Patients with secondary cerebral hemorrhage such as intracranial aneurysm, arteriovenous malformation or tumor stroke; 5. Patients with poor compliance or going abroad may lead to difficult follow-up within one year; 6. Patients with serious incomplete information of multidimensional screening indicators, if there is no imaging data, will die immediately after admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical phenotype;Psychological Cognitive Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| CT and MRI imaging features;PiB-PET imaging of brain;CSF specific biomarkers;Genetic factors;Specific changes in the fundus;Characteristics of peripheral vessels based on skin biopsy technique;Recurrent intracerebral hemorrhage;Cognitive impairment;Ischemic events; | — |
Countries
China
Contacts
Public ContactSuiqiang Zhu
Tongji Hospital Affiliated to Huazhong University of Science and Technology
Outcome results
None listed