Different Patterns of Dexmedetomidine Administration on Intraoperative neuromonitoring (IONM) During Spine Surgery: An Evaluation of Clinical Safety.
Conditions
Interventions
blank group:normal saline(NS)
Dex 0.3ug/kg:Dexmedetomidine
Dex 0.4ug/kg:Dexmedetomidine
Dex 0.5ug/kg:Dexmedetomidine
Dex 0.6ug/kg:Dexmedetomidine
Dex 0.7ug/kg:Dexmedetomidine
Sponsors
Beijing Friendship Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-65 years; 2. Those objects of ASA grade I or II; 3. Patients who need electrophysiological monitoring for selective spinal surgery.
Exclusion criteria
Exclusion criteria: 1. Patients with congenital neurological dysfunction; 2. Patients taking antidepressants, sedatives, analgesics or alcoholism before operation; 3. Patients with severe dysfunction of kidney, heart, liver and other functional organs; 4. Family members or patients who refused to participate in the study; 5. Patients who failed to carry out electrophysiological monitoring during operation due to various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Somatosensory evoked potential amplitude;Somatosensory evoked potential latency;motor evoked potential amplitude;Motor evoked potential latency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dosage of general anesthetic drugs;Postoperative complications; | — |
Countries
China
Contacts
Public ContactLixin An
Beijing Friendship Hospital Affiliated to Capital Medical University
Outcome results
None listed