Intracranial Lesions
Conditions
Interventions
Group R:0.5% ropivacaine 36ml
Group RS:Dexamethasone 10mg+0.5% ropivacaine (36ml)
Group RM:Dexmedetomidine 1ug/kg+0.5% ropivacaine (36ml)
Group RN:Nalbuphine 10mg+0.5% ropivacaine (36ml)
Sponsors
Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with preoperative intracranial space occupying or intracranial vascular diseases should be selected for craniotomy; 2. Patients with ASA grade I-III had no severe cardiopulmonary and other systemic and mental diseases; 3. The subjects with informed consent in this study have good cooperation.
Exclusion criteria
Exclusion criteria: 1. Patients whose incision is beyond the block area; 2. Patients with operation time more than 5 hours; 3. Patients with obvious abnormal heart, liver and kidney function, severe electrolyte disorder and obvious organic diseases before operation; 4. Patients with bradycardia and heart block; 5. Patients with allergic history of any research drug or anesthetic, history of chronic pain, long-term use of opioids or benzodiazepines; 6. Patients with preoperative disturbance of consciousness and abnormal communication have postoperative cognitive dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale /Score (VAS);blood pressure;heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay score; | — |
Countries
China
Contacts
Public ContactChen Chen
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed