Depression
Conditions
Interventions
Group 1:iTBS(L-DLPFC), SSRIs, SSNIs antidepressant
Group 2:iTBS(L-V1), SSRIs, SSNIs antidepressant
Sponsors
Zhongda Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Subjects who meet or reach the diagnostic criteria of unipolar depression; 2. Subjects with Hamilton Depression Scale (17 items) score >= 18; 3. Subjects aged 18-55 years; 4. The subjects who signed the informed consent voluntarily and were able to comply with the treatment plan and complete all the studies; 5. The subjects without obvious mental retardation can understand the questionnaire and evaluate the related questions.
Exclusion criteria
Exclusion criteria: 1. Patients with the following diseases: schizophrenia, paranoia, bipolar disorder, dementia, or other severe cognitive impairment, mental disorders caused by physical diseases or substance abuse; 2. Patients with history of brain trauma or other known organic diseases of central nervous system; 3. The subjects with psychotic symptoms and suicidal behavior in the course of depression attack; 4. Subjects with endocrine disease, blood disease or obvious abnormality of heart, liver and kidney function; 5. Patients who had received electroconvulsive therapy or rTMS; 6. Subjects who are taking antidepressants other than SSRIs and SNRIs and do not accept dressing change; 7. Patients with contraindications of rTMS or MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17-item Hamilton Rating Scale for Depression;adverse events scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery Depression Rating Scale;Beck suicide ideation scale;life events scale;mini-mental state examination;Montreal cognitive assessment;cognitive task;visual evoked potential;event-related potential P300; | — |
Countries
China
Contacts
Public ContactZhijun Zhang
Zhongda Hospital
Outcome results
None listed