gastrointestinal disease and anesthesia in elderly patients
Conditions
Interventions
Group 1:Remimazolam Tosilate
Group 2:Propofol
Sponsors
Anesthesiology Dept. The Eighth Afliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 65 and 80 years patients regardless of sex who receive routine gastroscopy; 2. ASA class for I-III; 3. BMI 18kg/m^2-30kg/m^2; 4. Planing to receive gastrointestinal endoscopy From October 2020 to October 2021; 5. The patient or family member fully understood the purpose and significance of this experiment, volunteered to participate in this clinical trial, and signed informed consent.
Exclusion criteria
Exclusion criteria: Patients with any of the following items cannot be enrolled in this study: 1.Complex endoscopic techniques (such as cholangiopancreatography, endoscopic ultrasonography, endoscopic mucosal resection, endoscopic submucosal dissection, transoral endoscopic myotomy, etc.). 2.The management of airways were judged to be difficult (Mallampati score of 3) and required trachea cannula. 3.Anemia,thrombocytopenia, abnormal liver function and abnormal renal function, or had a sitting systolic blood pressures of <= 90 mmHg, or had hypertension that was not satisfactorily controlled using antihypertensive drugs. 4.Drug abuse and/or alcoholism within 2 years. 5.Sensitivity to benzodiazepines, opioids, propofol, lidocaine or a contraindication to receiving these medications. 6.Participating any clinical trials of other drugs within 3 months before study initiation. 7.ASA class iv/v, a history of myocardial infarction within 6 months, severe conduction block, malignant arrhythmia, asthma persistence, severe lung infection, allergic constitution, neuromuscular disease, epilepsy history, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to adequate sedation;Sedation recovery time;Incidence of hypotension;The incidence of treatment-related hypotension;the incidence of respiratory depression;the percentage of patients in each group who were ready for discharge within 30min of procedure end time; | — |
Countries
China
Contacts
Public ContactCongcai Ren
The Eighth Afliated Hospital of Sun Yat-Sen University
Outcome results
None listed