critically ill patients
Conditions
Interventions
TDM group:Nil
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients were admitted to the ICU, and aged >= 18 years; (2) Patients were diagnosed with a proven, probable, and possible invasive fungal disease, or with high risk factors for fungal infection; (3) Using voriconazole for >= 7 d; (4) Monitoring voriconazole blood concentration at least once at a steady state (3 days after administration); (5) During voriconazole treatment, liver function tests should be performed at least once weekly.
Exclusion criteria
Exclusion criteria: (1) Pregnant women and patients are allergic to voriconazole; (2) Voriconazole blood concentration is lower than the lower limit of detection; (3) The time of administration of Medication is uncertain and laboratory test results are unavailable; (4) According to CTCAE standards, patients with liver dysfunction is greater than grade 3 or above when admitted to ICU; (5) Patients with severe liver diseases such as viral hepatitis, cirrhosis, drug-induced liver damage, liver cancer when admitted to ICU.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| voriconazole plasma concentration;hepatotoxicity; | — |
Countries
China
Contacts
Public ContactDong Yalin
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed