None listed
Conditions
Interventions
Group P :propofol 3µg /ml TCI
Group E1:etomidate 0.2µg/ml TCI and propofol 2µg/ml TCI
Group E2:etomidate 0.3µg /ml TCI and propofol 1.5µg /ml TCI
Group E3:etomidate 0.4µg /ml TCI and propofol 1µg /ml TCI
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Those patients who underwent gynecological endoscopic surgery within 2 hours under general anesthesia by the same team of surgeons; 2. Those patients whose operation time was from 8:00am to 14:00pm; 3. ASA I-II patients; 4. Patients aged 18-60 years; 5. Subjects with body mass index (BMI) 18-24kg / m2.
Exclusion criteria
Exclusion criteria: 1. Patients with severe hypertension; 2. Patients with coronary heart disease, diabetes and asthma; 3. Patients with shock; 4. Patients with hypothyroidism; 5. Patients with immune system diseases; 6. Patients with mental illness; 7. Patients with adrenocortical insufficiency; 8. Patients with severe hepatic and renal insufficiency; 9. Patients with history of hormone and other immunosuppressive agents; 10. Patients with a history of opioid and narcotic abuse; 11. Subjects with history of reoperation, allergy or inability to evaluate the quality of sleep and recovery; 12. If the operation time is less than 1 hour or more than 2 hours, or open surgery is adopted, the patients will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sleep duration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure (MAP);heart rates (HR);BIS values;the use of vasoactive agents;duration of eyelid loss;duration of awakening and extubation;remifentanil dose;the scores of observer's assessment of alertness/sedation scale (OAA/S);NRS;side effects;FSS scores;QoR-40 scores;PSQI scores; | — |
Countries
China
Contacts
Public ContactTao Yuzhu
Tianjin Medical University General Hospital
Outcome results
None listed