Spinal Cord Injury
Conditions
Interventions
Intervention group:Basic treatment + Symptomatic treatment + Laminectomy + Neurotropin
Control group:Basic treatment + Symptomatic treatment + Laminectomy + Normal saline
Sponsors
Shandong University Qilu Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18-65 years; 2. Subjects with complete behavioral ability who are willing and able to participate in the follow-up study; 2. Patients with complete spinal cord injury: Asia A-B injury; 3. Patients within 48 hours after injury; 4. Patients with other lesions were excluded by MRI scan in the injured area; 5. Subjects without other compound injuries.
Exclusion criteria
Exclusion criteria: 1. Patients with severe opportunistic infection or opportunistic tumor; 2. Patients with abnormal blood routine examination (leucocyte < 3 x 10^9 /L, hemoglobin < 90g/L, neutrophil < 1.5 x 10^9/L, platelet < 75 x 10^9 /L); 3. Patients with definite liver disease (HBsAg / HCV antibody positive), or abnormal liver function (ALT and / or ast more than 3 times of the upper limit of the normal value, or total bilirubin more than 2 times of the upper limit of the normal value); 4. Patients with renal insufficiency (glomerular filtration rate < 70ml / min or creatinine above the upper limit of normal value); 5. Patients with severe chronic diseases, metabolic diseases (such as diabetes), neurological and mental diseases, active bleeding, severe hypertension, severe thrombocytopenia and hyperkalemia; 6. Patients with previous pancreatitis; 7. Pregnant and lactating women; 8. Patients with allergic constitution or known allergy to the ingredients of the drug and the background drugs specified in the protocol; 9. Suspected or confirmed patients with history of alcohol and drug abuse; 10. Those who participated in clinical trials of other drugs (except traditional Chinese Medicine) within three months before screening; 11. Other factors considered unsuitable for the trial by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ASIA spinal cord injury score ;Neuroelectrophysiological examination ;MRI;Cerebrospinal fluid test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Routine examination;Imaging and ultrasonography examination; | — |
Countries
China
Contacts
Public ContactShiqing Feng
Shandong University Qilu Hospital
Outcome results
None listed