Healthy
Conditions
Interventions
control group:placebo
low-dose group:Low concentration of BL-99 bacterial powder
high-dose group:high concentration of BL-99 bacterial powder
Sponsors
China Agricultural University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18 to 60 years; 2. People who are willing to provide demographic information (age, race); 3. Those who are willing to complete the daily and weekly questionnaires on general health, intestinal function and gastrointestinal symptoms; 4. Those who are willing to provide 4 blood and 4 stool samples; 5. Those who are willing to stop any dietary supplements to enhance immunity; 6. People who can take probiotics without the help of others.
Exclusion criteria
Exclusion criteria: 1. Pregnant subjects; 2. The subjects of smoking and drinking; 3. Take any medicine to treat constipation or diarrhea; 4. The subjects who are taking any anti-inflammatory drugs regularly at present; 5. People who usually eat fermented food or probiotics (e.g. yoghurt with active culture or supplement); 6. Subjects who received antibiotic treatment in the past three months; 7. Subjects with clinical significance of diarrhea or Clostridium difficile infection in the past three months; 8. Patients with stool transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intestinal flora;Fecal metabolite; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;TNF-a;Short Chain Fatty Acids;Pepsinogen I/II;Gastrin; | — |
Countries
China
Contacts
Public ContactRen Fazheng
Department of Nutrition and Health, China Agricultural University
Outcome results
None listed