Perioperative management
Conditions
Interventions
Oral glucose group:Oral 5% glucose solution 5ml/kg 2 h before operation (<=400ml)
Intravenous glucose group:After anesthesia - induced intubation, 250ml 5% glucose solution was administered intravenously
Sponsors
The First Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 50-70 years; 2. ASA I-II; 3. The anesthesia time for the patients with the estimated operation time of 1-3 hours during daytime endoscopic surgery is 2-4 hours; 4. Patients with no history of allergy to narcotic drugs; 5. Patients without dyspnea or contraindications for intubation or LMA use; 6. Patients without mental disorder and related history; 7. Patients who were not operated for the second time in recent 3 months; 8. Patients who voluntarily entered the clinical trial.
Exclusion criteria
Exclusion criteria: 1. Patients with fasting blood glucose more than 6.1mmol/l or diabetes history; 2. Patients with important organ diseases or endocrine disorders; 3. Patients who received antiemetic or steroid therapy before operation; 4. Patients who have recently used drugs that affect glucose metabolism and insulin secretion; 5. The object of pregnancy; 6. Subjects with history of taking psychotropic drugs or definite history of mental illness; 7. Subjects with a history of alcohol abuse or drug dependence; 8. Subjects with history of POCD, cerebral organic disease or cerebrovascular accident; 9. Those who have been educated for less than 6 years; 10. People who are unable to communicate, such as impaired visual and auditory perception, language disorder, severe dementia or coma; 11. The subjects with positive cam score before operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PONV;Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood ketone;blood glucose; | — |
Countries
China
Contacts
Public ContactWang Yuelan/ SunYongtao
The First Affiliated Hospital of Shandong First Medical University
Outcome results
None listed