Efficacy of Closed-loop Functional Spinal Cord Stimulation on Walking Rehabilitation in Patients With Stroke (COFUN)

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000039277

Enrollment

Unknown

Registered

2020-10-22

Start date

2020-10-30

Completion date

Unknown

Last updated

2021-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Experimental group:Spinal Cord Stimulation

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. People aged 18-50 years; 2. Subjects 12 months after stroke; 3. The lesion was located in the basal ganglia of thalamus or motor cortex; 4. Subjects with unilateral lower limb muscle strength grade 3 or below; 5. Subjects unable to stand and walk independently; 6. Subjects that can stand with crutches or walking aids; 7. The subjects who have completed the in-hospital rehabilitation training after stroke; 8. The subjects with stable and healthy physiological conditions shall be judged by the researchers; 9. Good out of hospital care and rehabilitation; 10. Ensure that the subjects who can complete the whole research cycle cooperate to complete the rehabilitation training; 11. Subjects who completed at least one cycle of rehabilitation training with high quality before enrollment.

Exclusion criteria

Exclusion criteria: 1. Patients with walking disorders caused by other central nervous system diseases (tumor, inflammation, etc.); 2. Subjects of cognitive impairment; 3. The subject of language barrier; 4. Subjects of epilepsy; 5. Severe spinal stenosis 6. Subjects with implanted cardiac pacemakers or neuromodulatory devices; 7. Severe abnormal joint movement, muscle atrophy and abnormal muscle tension; 8. The subject of coagulation disorder; 9. Subjects with congenital lower limb dyskinesia; 10. Subjects unable to cooperate with clinical trials; 11. Alcohol or drug addicts; 12. The expected survival was less than 12 months; 13. The researchers believe that the participants' accompanying diseases or health conditions affect the completion of the trial.

Design outcomes

Primary

Measure	Time frame
Gait Improvements;10-metre Walking Test;Weight Bearing Capacity;	—

Countries

China

Contacts

Public ContactLuming Li

National Engineering Laboratory for Neuromodulation, Tsinghua University

lilm@tsinghua.edu.cn+86 13269102295

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026