Medicine
Conditions
Interventions
propofol group:propofol
Sponsors
The Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18-75 years old, regardless of gender; 2. Subjects classified as I - III by ASA; 3. 18 kg / m2 < BMI < 28 kg / m2; 4. Patients who are going to undergo cardiac surgery; 5. The patients participated voluntarily and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. The subjects who are allergic or contraindicated to benzodiazepines, opioids, propofol, naloxone and their drug groups; 2. Patients with severe respiratory diseases (obstructive sleep apnea syndrome, acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 3. Patients with uncontrolled hypertension or poorly controlled hypertension (sitting systolic blood pressure >= 160 mmHg and / or diastolic blood pressure >= 100 mmHg in screening period); 4. Subjects with abnormal liver and kidney function: ALT and / or ast exceeding 1.5 times of the upper limit of the medical reference range; creatinine or blood urea nitrogen or blood urea exceeding the upper limit of the medical reference range; 5. Mental patients; 6. Pregnant women or patients preparing for pregnancy in the near future; 7. Patients with long-term alcoholism or use of benzodiazepines and opioids; 8. Patients with difficult airway: Mahalanobis grade III or above.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Doses of vasoactive medications; | — |
Countries
China
Contacts
Public ContactYan Zhenyi
The Affiliated Hospital of Guangdong Medical University
Outcome results
None listed