Effects of different crystal fluids on homeostasis and vascular end othelium in patients with septic shock

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000039226

Enrollment

Unknown

Registered

2020-10-22

Start date

2020-10-22

Completion date

Unknown

Last updated

2021-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

septic shock

Interventions

LR group:Lactated Ringer’s solution

AR group:Ringers acetate solution

BR group:sodium bicarbonate Ringer's solution

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: (1) Patients 18 years of age or older; (2) Meet the diagnostic criteria set out in the 2016 Guidelines for sepsis.(after full fluid resuscitation, patients with severe infection still need to apply vasoactive drugs to maintain mean arterial pressure (MAP) >= 65mmHg (1mmHg = 0.133kpa), accompanied by blood lactate (Lac) > 2mmol/L; (3) It was approved by the ethics Committee of the hospital, and all patients or legally authorized representatives signed informed consent.

Exclusion criteria

Exclusion criteria: (1) History of chronic renal insufficiency; (2) Autoimmune diseases; (3) Diseases of blood system; (4) Brain injury and endocrine diseases cause electrolyte disturbance; (5) Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
syndecan-1;	—

Countries

China

Contacts

Public ContactLiu Ya

The Second Hospital of Hebei Medical Universtiy

md2006liuya@aliyun.com+86 15803217957

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026