Hypertension
Conditions
Interventions
experimental group:allisartan 240mg, indapamide 1.5mg
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Inform concerned prior to screening, acknowledgement of protocol, procedure and AE; 2. Able to complete the study follow by the protocol; 3. Subjects (including partners) are willing to voluntarily take effective contraceptive measures within 6 months from screening to the last study drug administration. See Appendix for specific contraceptive measures; 4. Male and female subjects aged 18-45 (including 18 and 45 years old); 5. The body weight of male subjects is no less than 50kg, and that of female subjects is no less than 45kg; body mass index (BMI) = body weight (kg) / height 2 (M2), body mass index is in the range of 18-28kg / m2 (including the critical value); 6. Physical examination and vital signs are normal or abnormal without clinical significance; systolic blood pressure > 100 and = 60 and < 90mmHg, without postural hypotension. 7. 3.5<=blood potassium<=5.5mmol/L.
Exclusion criteria
Exclusion criteria: 1. The subjects who smoked more than 5 cigarettes per day in the three months before the experiment and could not guarantee to quit smoking during the experiment; 2. Those who are known or suspected to have allergic reactions to allisartan, losartan, indapamide and their accessories of the product; or ARB, or Thiazides and thiazines or allergic constitution (multiple drugs and food allergy); 3. Subjects with a history of drug and / or alcohol abuse (14 units of alcohol per week: 1 unit = 285 ml of beer, or 25 ml of spirits, or 100 ml of wine); 4. Blood donation or massive blood loss within three months before screening (> 450 ml); 5. Difficulty in swallow or any stomach diseases that influence the absorption of drugs; 6. Any risks of bleeding diseases, such as Hemorrhoids, acute gastritis or gastric and duodenal ulcer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cmax,ss;AUC0-tau,ss; | — |
Countries
China
Contacts
Public ContactYing Wang
Zhejiang Provincial People's Hospital
Outcome results
None listed