Hepatectomy
Conditions
Interventions
Group G:Terlipressin was infused continuously during the operation
Group T:Nitroglycerin was used at the beginning of operation to achieve the goal of controlled low central venous pressure
Sponsors
Department of Anesthesiology, the First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged from 18 to 65 years old, regardless of gender; 2. ASA I - II, cardiac function grade 1; 3. The patients who were diagnosed as primary liver cancer before operation were confirmed as hepatocellular carcinoma, cholangiocarcinoma or mixed cell carcinoma by postoperative pathology; 4. Patients undergoing elective partial hepatectomy (residual liver volume > 40%); 5. The liver function was child Pugh grade: Grade A, or grade B was improved to grade A by preoperative treatment; 6. Patients with normal renal function before operation.
Exclusion criteria
Exclusion criteria: 1. Patients with grade 3 or above hypertension or uncontrolled grade 1-2 hypertension (daily blood pressure > 140 / 90mmHg after taking antihypertensive drugs); 2. Patients with cardiovascular and cerebrovascular diseases (coronary heart disease, cerebral infarction, etc.); 3. Patients with BMI > 30kg / m2; 4. Patients with known allergy to terlipressin or nitroglycerin; 5. Patients with active hepatitis; 6. Patients with liver cancer complicated with large vessel invasion, recurrence of liver cancer and reoperation; 7. Patients with active gastrointestinal bleeding, liver dysfunction, severe and uncorrectable coagulation dysfunction, or other contraindications of terlipressin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Drainage volume of postoperative ascites;Urine output; | — |
Countries
China
Contacts
Public ContactHuang Xiongqing
Department of Anesthesiology, the First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed