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An observational study of ctDNA in evaluating postoperative recurrence and adjuvant treatment efficiency after surgical treatment of colorectal cancer with liver metastasis

An observational study of ctDNA in evaluating postoperative recurrence and adjuvant treatment efficiency after surgical treatment of colorectal cancer with liver metastasis

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000039130
Enrollment
Unknown
Registered
2020-10-17
Start date
2019-05-01
Completion date
Unknown
Last updated
2021-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Gold Standard:Clinical outcomes

Sponsors

Shanghai Cancer Center affiliated to Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients aged from 18 to 80, regardless of gender; 2. Patients with liver metastasis of colorectal cancer confirmed by pathological diagnosis; 3. Patients with complete resection (R0) of primary colorectal cancer and liver metastases; 4. Patients whose postoperative general condition allows chemotherapy; 5. Patients whose expected survival time is more than 6 months; 6. There are enough surgical or biopsy specimens for gene detection; 7. The subjects (or their legal representative / Guardian) must sign the informed consent, indicating that they understand the purpose of the study, understand the necessary procedures of the study, and are willing to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Patients with active bleeding of clinical significance; 2. Those who are addicted to alcohol or drugs; 3. Patients with important organ failure or other serious diseases, including clinical related coronary artery disease, cardiovascular disease or patients with myocardial infarction, congestive heart failure, unstable angina pectoris, symptomatic pericardial effusion or unstable arrhythmia within 6 months before enrollment; 4. Patients with severe neurological or psychiatric history; severe infection; active disseminated intravascular coagulation or other accompanying diseases that seriously endanger the safety of patients or affect the completion of the study according to the judgment of the researchers.

Design outcomes

Primary

MeasureTime frame
accuracy;

Secondary

MeasureTime frame
accuracy on efficacy;overall survival;recurrence free survival;

Countries

China

Contacts

Public ContactLu Wang

Shanghai Cancer Center affiliated to Fudan University

wang.lu99@hotmail.com+86 13601678615

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026