Postpartum Depression
Conditions
Interventions
High-dose esketamine group:After delivery, participants received 0.25mg/kg intravenous esketamine (diluted to 10 mL with 0.9% saline
infusion time: 10min). The PCIA protocol was 2.2ug/kg sufentanil + 2.0mg/kg esketamine diluted to 100ml (infusion rate: 2 mL/h
infusion time: 48h)
Low-dose esketamine group:After delivery, participants received 0.25mg/kg intravenous esketamine (diluted to 10 mL with 0.9% saline
infusion time: 10min). The PCIA protocol was 2.2ug/kg sufentanil + 1.0mg/kg esketamine diluted to 100ml (infusion rate: 2 mL/h
Sponsors
The Anesthesia Department of the Third Xiangya Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients over 18 years old; 2. ASA II patients; 3. Patients with gestation more than 28 weeks; 4. Patients requiring postoperative analgesia; 5. Patients with preoperative EPDS score >= 10; 6. Patients without serious cardiovascular and cerebrovascular diseases; 7. The puerpera can communicate well with the follow-up; 8. Patients who voluntarily participated in this study and signed relevant informed consent.
Exclusion criteria
Exclusion criteria: 1. Puerpera who require general anesthesia or natural labor; 2. Patients with unstable mental illness or depressive disorder; 3. Patients with severe cardiovascular and cerebrovascular diseases; 4. Patients with history of ketamine or other drugs abuse; 5. Patients who took a certain drug for a long time in the first 6 months of the study; 6. Patients with long-term drinking habit are allergic to ketamine; 7. Patients who do not have the ability to understand the language of the follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The PPD prevalence; | — |
Secondary
| Measure | Time frame |
|---|---|
| The prevalence of postpartum blues;Self-harm idea;Ramsay sedation scores;NRS score;Insomnia severity index; | — |
Countries
China
Contacts
Public ContactDuan KM, Wang SY
The Anesthesia Department of the Third Xiangya Hospital
Outcome results
None listed