Carotid atherosclerosis
Conditions
Sponsors
Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with carotid atherosclerotic plaque diagnosed by color Doppler ultrasound; 2. Patients with hs CRP >= 2mg / L; 3. Patients aged between 40 and 80, regardless of gender; 4. Patients who can take medicine for a long time; 5. Patients who have informed consent shall sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with acute or subacute hemorrhage in plaque; 2. Patients with complete calcification and fibrosis of plaque; 3. MRI contraindications (such as pacemaker, denture, stent, etc.); 4. Patients with active ulcer and bleeding tendency, long-term use of anticoagulant drugs (such as warfarin); 5. Patients using dual antiplatelet drugs; 6. Patients with severe arrhythmia, atrial fibrillation and heart failure; 7. Patients with severe primary diseases such as liver, kidney, hematopoietic system, endocrine system and respiratory system, whose liver function is more than 1.5 times higher than the upper limit of normal value, and Cr is higher than the normal value; 8. Patients with any other life-threatening or serious diseases can not complete the 12-month treatment, so as to affect the evaluation results; 9. Pregnant or lactating women, women with short-term pregnancy plans; 10. Patients with allergic constitution; 11. Patients with other diseases or psychosis that the researchers believe may limit the efficacy evaluation or follow-up of patients; 12. Patients who have participated in clinical trials of other drugs in recent 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimum fiber cap thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Volume of Lipid-Rich Necrotic Core;Volume percentage of Lipid-Rich Necrotic Core;Carotid Atherosclerosis Score;Volume of Fiber cap;Volume percentage of Fiber cap;Volume of bleeding in plaque;Volume percentage of bleeding in plaque;Volume of plaque calcification;Volume percentage of plaque calcification;Vascular stenosis rate;Average value of vascular wall thickness;Maximum vascular wall thickness;Volume of vascular wall;Total vessel wall load (volume of vascular wall/total volume of blood vessels);Weight;Blood lipid;Blood glucose;Blood pressure;High-sensitivityC-reactive protein; | — |
Countries
China
Contacts
Public ContactWu Shengxian
Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
Outcome results
None listed