Parkinson's Disease
Conditions
Interventions
Group 1:adding pramipexole
Group 2:adding LCE
Sponsors
The Affiliated Brain Hospital of Nanjing Medical University (Nanjing Brain Hospital)
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Primary PD patients (according to MDS2015 Parkinson's Disease diagnostic criteria); (2) Aged 30-80 years, no gender limitationg; (3) WOQ-19 more than on positive; (4) The dose of levodopa >= 300mg/ day and need to adjust the current anti-Parkinson's drugs; (5) H-Y stage 1.5-4; (6) Daily "off" period >= 1.5 hours; (7) Signing the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with atypical Parkinson's syndrome or Parkinson's superimposed syndrome; (2) Performed any surgical treatment in the half year before the trial; (3) Patients with severe hypertension (blood pressure >= 180mmHg) and unsatisfactory control; (4) Patients with severe cerebral arteriosclerosis, cerebrovascular disease and limb dysfunction caused by cerebrovascular disease; (5) Alcoholism, drug addiction or severe mental impairment (including severe dementia), failure to take drugs on time and cooperation with the examiner (Simple Intelligence Status Check Scale;Illiteracy was 2.5 times of normal value; Renal dysfunction: the normal value of creatinine > is 1.5 times; (12) ECG abnormalities: clinically significant QT interval prolongation (450ms in male and 470ms in female), ventricular tachycardia, atrial fibrillation, and heart block.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 'off' time; | — |
Secondary
| Measure | Time frame |
|---|---|
| 'on' time;MDS-UPDRS; | — |
Countries
China
Contacts
Public ContactWeiguo Liu
The Affiliated Brain Hospital of Nanjing Medical University (Nanjing Brain Hospital)
Outcome results
None listed