Acute ischemic stroke
Conditions
Interventions
Thrombectomy and Hypothermia:Thrombectomy and Hypothermia
Sponsors
PLA Army Characteristic Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with acute ischemic stroke involving ICA and M1, aged >= 18 and = 15 and dominant hemisphere >= 20 at admission. 4. Patients with ncct-aspects score of 3-5 and meeting the following evaluation criteria at the same time: (1) Core infarct volume (rCBF decreased to less than 30% of the contralateral) >= 50ml and = 15ml [(Tmax >= 6S volume) - (core infarct volume)]; (3) Ischemic area (Tmax >= 6S) volume / core infarct volume >= 1.5; 5. For patients whose time from onset to puncture is less than 12 hours, the time from imaging to puncture is less than 1.5 hours, and the time from puncture to tici2b3 is less than 1 hour; 6. The patients with good vascular path can meet the needs of subsequent hypothermia treatment; 7. The patient or the legal representative of the patient voluntarily signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with clinical signs of brain hernia, such as unilateral or bilateral pupil dilation, fixation, light reflex and other brainstem reflex disappeared. 2. Patients with severe renal disease history (such as dialysis), or EGFR 70%, those with postoperative stenosis not relieved are expected. 9. Patients with severe trauma and operation history within 3 months. 10. Patients with complete atrioventricular block. 11. According to the New York Heart Association (NYHA) heart function classification, patients with heart function rating above grade II and previous history of congestive heart failure (CHF). 12. Patients with current drug or alcohol problems or experiences. 13. Patients who participated in the study were not considered suitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptomatic intracranial hemorrhage;the incidence of midline structure shift more than 5 mm within 48 hours of onset with unilateral or bilateral mydriasis and fixation; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS??;GCS;FOUR score;midline structure shift;intracranial pressure;mRs; | — |
Countries
China
Contacts
Public ContactLi Wei
PLA Army characteristic medical center
Outcome results
None listed