Effects of hypertonic saline on cerebral perfusion in patients with severe aneurysmal subarachnoid hemorrhage

Clinical study on the effect of hypertonic saline on cerebral perfusion in severe aSAH patients based on the regulation of blood sodium level

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000038970

Enrollment

Unknown

Registered

2020-10-11

Start date

2020-10-01

Completion date

Unknown

Last updated

2021-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aneurysmal Subarachnoid Hemorrhage

Interventions

Hypertonic saline:Hypertonic saline

Mannitol:Mannitol

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with severe aSAH of hunt & Hess grade IV and V diagnosed by CTA or DSA; 2. Patients over 18 years old; 3. Patients with informed consent for cerebral aneurysm surgery (craniotomy clipping or interventional embolization) can cooperate with follow-up.

Exclusion criteria

Exclusion criteria: 1. Patients with brain death; 2. Patients with other organ diseases, such as: severe heart, lung, liver, kidney and other organ dysfunction and poor general condition; 3; 4. Patients with plasma osmolality greater than 320 mOsm / L; 5. Patients with severe water electrolyte disorder that cannot be corrected in a short time.

Design outcomes

Primary

Measure	Time frame
intracranial pressure;TCD;cerebral perfusion;	—

Countries

China

Contacts

Public ContactXuecai Huang

The Fifth Affiliated Hospital of Wenzhou Medical University

huangxc-ns@hotmail.com+86 13600601639

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026