Menopausal disease
Conditions
Interventions
Group 1:Femoston 1/0
Group 2:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
42 Years to 52 Years
Inclusion criteria
Inclusion criteria: a) Women aged 42-52 years. b) Intact uterus, visible in both ovaries under ultrasound. c) The difference in the length of the adjacent menstrual cycle is more than 7 days, it is repeated in 10 menstrual cycles, and there has been at least one menstrual cycle in the past 3 months. d) Menopausal symptoms are obvious, and the menopausal symptom scale (modified Kupperman score) >= 14 points. e) TCT results are normal within one year or TCT and HPV results are normal within three years. f) Patients who are willing to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: a) The presence of various malignant tumors or suspected malignant tumors (tumor marker examination results or breast ultrasound or pelvic ultrasound indicating suspected malignant tumors); b) A history of thrombosis within 6 months; c) Used sex hormone drugs (including various estrogen-containing drugs or compound oral contraceptives) that affect ovarian function in the recent 2 months; d) Used traditional Chinese or plant drugs in the past two months (such as Kuntai capsule, Xiangshao granules, Lifumin and other similar drugs) to affect the menopausal symptoms, as well as anti-anxiety and depression drugs and western drugs; e) A history of drug allergy or allergic constitution that may endanger life; f) Transaminase (ALT) and creatinine (Cr) exceeding 2 times of the normal value; g) Uterine fibroids >= 5cm; h) Body mass index >= 28 kg/m2; i) Subjects who are participating in other clinical trials or who have participated in other clinical trials within 3 months; j) Other circumstances in which the physician considers it inappropriate to participate in the study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| PSQI sleep score, depression and anxiety score, sexual function scale;physical examination;Vaginal microecological detection;sex hormone;BMD(bone mineral density);ultrasound;Menstrual diary, symptom diary; | — |
Primary
| Measure | Time frame |
|---|---|
| Kupperman Score Scale; | — |
Countries
China
Contacts
Public ContactZhu Lan
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital
Outcome results
None listed