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Comparative dose-response study on the infusion of norepinephrine combined with crystalloid coloading versus colloid coloading for preventing hypotension during spinal anesthesia for cesarean delivery

Comparative dose-response study on the infusion of norepinephrine combined with crystalloid coloading versus colloid coloading for preventing hypotension during spinal anesthesia for cesarean delivery

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000038925
Enrollment
Unknown
Registered
2020-10-10
Start date
2020-10-12
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal anaesthesia-induced hypotension during cesarean section

Interventions

Sponsors

Womens' Hospital, School of Medicine, Zhejiang University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) ASA grade II; (2) parturients aged 18 to 40 years; (3) BMI = 37 weeks), elective Single-birth cesarean section.

Exclusion criteria

Exclusion criteria: (1) contraindication of intraspinal anesthesia; (2) allergy to amide local anesthetics; (3) baseline systolic blood pressure (SBP) 140 mmHg; (4) pregnancy induced hypertension or preeclampsia; (5) gestational diabetes mellitus; (6) asthma and cardiac diseases requiring treatment; (7) refusal to sign informed consent; (8) its Other conditions: such as ruptured membranes, active labor process, intrauterine growth restriction, placenta previa, fetal congenital abnormalities, etc..

Design outcomes

Primary

MeasureTime frame
Incidence of hypotension;

Secondary

MeasureTime frame
Number of interventions;Dosage of vasoactive drugs;Neonatal outcomes (umbilical vein blood gas results, 1 - and 5-minute Apgar scores);Maternal outcomes (Nausea and Vomiting; Bradycardia; Tachycardia; Hypertension; Dizzy; Dyspnea);

Countries

China

Contacts

Public ContactXiaowei Qian

Womens' Hospital, School of Medicine, Zhejiang University

qxwzhejiangedu@163.com+86 15700157161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026