Acute promyelocytic leukemia in children
Conditions
Interventions
Control group:Induction therapy
Experimental group:Induction therapy+idarubicin
Sponsors
The First Affiliated Hospital of Sun Yat sen University
Eligibility
Sex/Gender
All
Age
No minimum to 16 Years
Inclusion criteria
Inclusion criteria: 1. Patients under 16 years old; 2. Patients with PML-RAR a / T (15; 17) positive acute promyelocytic leukemia (APL); 3. Newly diagnosed patients.
Exclusion criteria
Exclusion criteria: 1. Patients with intracranial hemorrhage and one of the following manifestations: coma, convulsion, hemiplegia, cranial nerve paralysis. 2. Patients with CNSL and one of the following manifestations before enrollment: coma, convulsion, hemiplegia, cranial nerve paralysis. 3. Patients whose QTc of ECG is not more than 500ms cannot use RIF normally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coagulation function;Cardiac function;basic value of Urine arsenic;Routine examination before treatment of leukemia;Relief rate;five year event-free survival rate;ten year event-free survival rate;Overall survival rate;Arsenic excretion and residue;Cumulative hospitalization time;Cost of treatment;MRD;hyperleukocytosis;introduction differentiation syndrome; | — |
Countries
China
Contacts
Public ContactYanlai Tang
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed