Myasthenia gravis
Conditions
Interventions
Myasthenia Gravis Case Group:N/A
Sponsors
Department of Neurology, The Second Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 90 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed by a neurologist as myasthenia gravis (Myasthenia gravis, MG); 2. Agree to receive blood and DNA sample collection; if it is a patient with thymoma, agree to obtain a postoperative thymus specimen; 3. Complete imaging and accept each special evaluation of this research; 4. Voluntarily sign the informed consent form (child patients are signed by their legal representatives; if the child patients can participate in research discussions, they must obtain their own consent).
Exclusion criteria
Exclusion criteria: 1. Severe anxiety, depression and schizophrenia; 2. The Simple Mental State Score (MMSE) for patients >= 14 years old is <= 24 points; 3. Patients with other serious systemic diseases whose expected survival is less than 2 years and cannot complete the follow-up; 4. Those who refuse to participate in the registration survey or are expected to have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The generalization rate and risk factors for the generaliza of OMG patients to systemic type at the last follow-up;Change in Quantitative Myasthenia Gravis (QMG) Scores from Baseline to follow up;Change in MG-ADL Scores from Baseline to follow up;Time to reach MMS status in patients receiving immunosuppressive therapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative dose/time weighted dose of steroid;Cumulative maintenance time of MMS state;The proportion of side effects in patients receiving immune preparations;Changes of B lymphocytes in patients receiving rituximab treatment; | — |
Countries
China
Contacts
Public ContactChangTing
The Second Affiliated Hospital of Air Force Medical University
Outcome results
None listed