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Effect of Different Doses of Dexmedetomidine Combined with Ropivacaine for Preventing of Visceral Traction Reaction during Caesarean Section under Epidural Anesthesia

Effect of Different Doses of Dexmedetomidine Combined with Ropivacaine for Preventing of Visceral Traction Reaction during Caesarean Section under Epidural Anesthesia

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000038853
Enrollment
Unknown
Registered
2020-10-07
Start date
2020-12-01
Completion date
Unknown
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Visceral Traction Reaction during Caesarean Section

Interventions

control group:saline 2ml
experimental group 1:0.5µg /kg Dexmedetomidine 2ml
experimental group 2:0.75µg /kg Dexmedetomidine 2ml
experimental group 3:1 µg /kg Dexmedetomidine 2ml

Sponsors

Department of Anesthesia, the First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
19 Years to 38 Years

Inclusion criteria

Inclusion criteria: 1. Pregnant women in our hospital who intend to undergo cesarean section in the lower uterine segment under continuous epidural anesthesia during single term pregnancy, and participate in the study voluntarily and sign the informed consent. 2. Routine blood and blood coagulation function abnormality was not found, 3. No history of bleeding, no pregnancy-induced hypertension syndrome, endocrine and nervous system disease, fetal intrauterine hypoxia, no spirit, nervous system diseases, motion sickness, maternal diabetes, heart, lung and kidney dysfunction, 4. ASA I - II level, 5. Aged 19-38 years, weight 55-82 kg; 6. No history of sedative and analgesic drugs, antidepressants, corticosteroids, vasoactive drugs, etc.

Exclusion criteria

Exclusion criteria: 1. Epidural anesthesia puncture operation failed and other anesthesia methods were used. 2. Intraoperative massive hemorrhage; 3. Allergic reaction to a2 adrenergic agonists or local anesthetics; 4. Severe drug allergic reaction occurred during the operation; 5. Severe complications such as total spinal anesthesia occurred during the operation.

Design outcomes

Primary

MeasureTime frame
Visceral Traction Reaction;NRS score;onset time of sensory block;level of sensory block;Hemodynamic characteristics;

Secondary

MeasureTime frame
complication;Apgar score;

Countries

China

Contacts

Public ContactWang Bin

The First Affiliated Hospital of Chongqing Medical University

774935778@qq.com+86 13637815096

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026