Alzheimer's disease
Conditions
Interventions
Individualized frequency group:Individualized frequency rTMS
Individualized intensity group:Individualized intensity rTMS
Individualized frequency+intensity group:Individualized frequency+intensity rTMS
Control group:Conventional rTMS
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) The age is 55-80 years old. 2) Patients or informants complained of progressive decline in memory function over 6 months. 3) Right handed. 4) Meet the AD diagnostic criteria in DSM-5. 5) 0.5 points = 26 points. 10) Head MRI or CT: Medial Temporal lobe Atrophy Scale (MTA-Scale) is graded 2 or higher; except for brain space and infection; no hemorrhage; intracerebral infarction The lesions are less than 3 and the diameter of the lesions is not more than 1.0cm, and they are all located in the semi-oval center or the basal ganglia area and other non-critical parts. Mild white matter demyelination changes near the sides of the ventricle are allowed; the white matter damage grade >= 3. 11) Have a stable carer (at least 3 days a week, at least 2 hours a day). 12) To participate voluntarily, the patient and/or legal guardian shall sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Major medical diseases of heart, liver, lung, pancreas and kidney. 2) History of brain trauma. 3) Central nervous system organic diseases/infectious/vascular diseases and other nervous system diseases. 4) History of mental disorders. 5) The body has implanted metal/electronic equipment, and cannot complete CT, MRI examination/TMS treatment. 6) The patient is not cooperative.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG;Cognitive scale; | — |
Countries
China
Contacts
Public ContactChen Wei
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed