Children's restlessness after general anesthesia
Conditions
Interventions
control group:Rimazollam group
group R: Rimazolom 0.1 mg / kg i.v
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 9 Years
Inclusion criteria
Inclusion criteria: (1) Laparoscopic hernia surgery under general anesthesia in 3-9 years old children; (2) ASA grade 1-2; (3) Body mass index 18-23; (4) The family members of the children voluntarily participated and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Known or suspected to be allergic or contraindicated to various components of the study drug or other opioids; (2) Analgesic, sedative, antiemetic and anti pruritus drugs were used 24 hours before operation; (3) Shock or coma; (4) Patients with bronchial asthma or respiratory depression; (5) Brain injury, intracranial injury or the presence of increased intracranial pressure; (6) There are chronic pain, long-term use of analgesics, psychiatric drugs (including opioids, NSAIDs, sedatives, antidepressants, etc.), alcohol abuse, drug abuse and addicts; (7) Liver and kidney function: ALT and / or ast exceed 1.5 times of the upper limit of medical reference value creatinine or urea nitrogen beyond the normal range; (8) Severe arrhythmia, cardiac insufficiency (NYHA grade >= III), unstable heart angina pectoris, acute myocardial infarction in recent 6 months, no regular antihypertensive treatment or blood pressure control; Patients with poor performance (SBP >= 160 mmHg and / or DBP>= 100 mmHg) or (SBP <= 90 mmHg and / or DBP <= 60 mmHg); (9) Those who cannot give full informed consent due to mental disorders and cannot express their wishes correctly; (10) Patients with a known history of neurological abnormalities, such as seizures; (11) Patients who have received any other trial drugs within 3 months before enrollment; (12) The researchers judged that the subjects' compliance was not good and could not strictly implement regime.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emergence agitation score; | — |
Countries
China
Contacts
Public ContactGu Xiaoxia
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed