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The dose-effect relationship of Tai-Chi-Chuan on mild cognitive impairment based on the default model network: a multimodal imaging study

The dose-effect relationship of Tai-Chi-Chuan on mild cognitive impairment based on the default model network: a multimodal imaging study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000038837
Enrollment
Unknown
Registered
2020-10-05
Start date
2020-10-20
Completion date
Unknown
Last updated
2022-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment

Interventions

Tai-Chi-Chuan group A:Tai-Chi-Chuan training (once a week for 24 weeks)
Tai-Chi-Chuan group B:Tai-Chi-Chuan training (3 times a week for 24 weeks)
Tai-Chi-Chuan group C:Tai-Chi-Chuan training (5 times a week for 24 weeks)

Sponsors

Fujian University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meet the MCI diagnostic criteria; 2. MOCA score < 26 points ; 3. Activities of Daily Living scale (ADL) score < 18 points; 4. The General Decline Scale (GDS) level was 2-3; 5. Between the ages of 60 and 75 years. F. No regular exercise in the last six months; G. Right handed; H. Have certain reading comprehension and communication skills, can cooperate to complete the scale evaluation; I. Informed consent and voluntary participation.

Exclusion criteria

Exclusion criteria: 1. Patients with hypertension whose blood pressure could not be controlled (systolic blood pressure greater than 160 mmHg or diastolic blood pressure greater than 100 mmHg); 2. History of alcohol and drug abuse; 3. Other reasons, such as severe anxiety, depression, drugs, poisoning, cerebrovascular disease caused by cognitive impairment; 4. The subjects with mental history (such as personality disorder, schizophrenia, etc.), or severe aphasia and visual impairment, or severe organ failure, myocardial infarction, coronary heart disease, musculoskeletal system diseases, sports contraindications, color blindness and low education level, etc. could not cooperate with the test; 5. Contraindications of MRI examination such as removable denture and cardiac pacemaker, taking opioids, benzodiazepines and other drugs that affect brain imaging; 6. Other researchers who are taking part in the study.

Design outcomes

Primary

MeasureTime frame
MOCA;

Secondary

MeasureTime frame
Memory function assessment;Attention assessment;Executive function assessment;Quality of life assessment;MRI scanning;Analysis of cortical nerve activity;Detection of Cognitive related factors in Peripheral Blood;

Countries

China

Contacts

Public ContactLiu Jiao

Fujian University of Traditional Chinese Medicine

liujiao0415@outlook.com+86 15860283226

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026