Remifentanil induced hyperalgesia
Conditions
Interventions
Nalbuphine (Group T):The patient was injected with 0.2mg/kg nalbuphine hydrochloride (diluted to 5ml with normal saline) 15min before anesthesia induction, and then the tube was flushed with normal sa
ketorolac tromethamine (Group T):The patient was injected with 0.5mg/kg ketorolac tromethamine (diluted to 5ml by adding normal saline) 15min before anesthesia induction, and then the tube was flushed
nalbuphine+ketorolac tromethamine (GroupN+T):The patient was injected with 0.2mg/kg nalbuphine hydrochloride (diluted to 5ml by adding normal saline) 15min before anesthesia induction, and injected wi
placebo (Group A):The patient was injected with 5ml normal saline 15min before anesthesia induction, and 5ml normal saline was injected again after flushing the tube
Sponsors
The First Affiliated Hospital of Henan University
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Optional thoracoscopic lobectomy; (2) Patients aged 20 to 65 years; (3) ASA class I~ II; (4) BMI18 ~ 30kg/m2; (5) General anesthesia was agreed, and sufentanil - based PCIA was accepted; (6) Can communicate with the doctor normally, cooperate with preoperative, intraoperative, postoperative evaluation and testing; (7) No serious cardiovascular disease and normal liver and kidney function; (8) Patients or their family members sign the informed consent form for this study.
Exclusion criteria
Exclusion criteria: (1) Allergic to nabulphine, ketorolac tromethamine or other drugs in this study; (2) The patient did not take analgesic and sedative drugs recently; (3) There is a serious mental nervous system disease; (4) The patient has a complex internal systemic disease; (5) A pregnant or lactating woman; (6) People considered unsuitable by researchers for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mechanical pain threshold; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative dosage of remifentanil;The number of times that PCA was effectively pressed within 24h after the patient was admitted to the ward;The time of the first effective pressure on PCA from the distance of extubation;Visual simulation scoring;Ramsay sedation score; | — |
Countries
China
Contacts
Public ContactZheng Xiao-Zhen
The First Affiliated Hospital of Henan University
Outcome results
None listed