Postoperative neurological dysfunction
Conditions
Interventions
Group C:Intravenous infusion of 20 ml normal saline
Group K:Esmamine 0.3mg/kg was diluted into 20ml IV pump for 20min
Group D:Dexmedetomidine was given 1 µ g · kg-1 · H-1 IV pump for 20 min
Group DK:Esmamine 0.3mg/kg and Dexmedetomidine 1 µ g · kg-1 · H-1 IV pump for 20 min
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Voluntary participation and ability to provide informed consent. (2) Patients undergoing the following operations in our hospital: non cardiac surgery, such as chest surgery, macrovascular surgery, abdominal surgery, gynecological open surgery, urology open surgery, major orthopedic surgery, hepatobiliary surgery and ENT surgery. (3) Aged >= 65 years old, BMI 18-30 kg / m2; (4) Three months before screening, she did not participate in clinical trials of other drugs.
Exclusion criteria
Exclusion criteria: (1) Patients who are allergic to active ingredients of dexmedetomidine or esmamine or all excipients; (2) Patients at serious risk of elevated blood pressure or intracranial pressure; (3) Poorly controlled or untreated hypertension (arterial hypertension, resting SBP / DBP over 180 / 100mmhg); (4) Combined with other important organ dysfunction: including severe liver and kidney dysfunction; brain organic disease, specifically refers to aneurysmal vascular disease or arteriovenous malformation and cerebral hemorrhage; severe hypertension, coronary heart disease, cardiac insufficiency (NYHA >= III), pulmonary hypertension; hematological diseases; coagulation dysfunction; severe respiratory diseases; severe respiratory diseases; severe hypertension, coronary heart disease, cardiac insufficiency (NYHA >= III grade), pulmonary hypertension; (5) Preeclampsia and eclampsia; (6) Untreated or undertreated patients with hyperthyroidism; (7) Use in cases where uterine muscle relaxation is required, for example, in the case of uterine laceration, umbilical cord prolapse; (8) A patient with a history of alcohol or drug dependence or drug abuse; (9) Patients taking antipsychotic drugs; Patients who were not considered suitable for inclusion by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PND; | — |
Countries
China
Contacts
Public ContactGu Xiaoxia
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed