Post-stroke cognitive impairment
Conditions
Interventions
PSIC group and non-PSCI group:Nil
Sponsors
Zhuhai People’s Hospital (Zhuhai Hospital affiliated with Jinan University)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patient is conscious, with stable vital signs and informed consent; 2. Patients aged > 18 years and < 80 years were right handedness; 3. The patients who met the criteria of "Chinese guidelines for the diagnosis and treatment of acute ischemic stroke 2014" were confirmed as acute ischemic stroke by head CT or MRI, and the head and neck vessels were evaluated by MRA, CTA or DSA; 4. This time was the first time, within 14 days after stroke, NIHSS score was less than 15; 5. Patients with normal cognitive function and mental behavior before the onset.
Exclusion criteria
Exclusion criteria: 1. Patients with ischemic stroke confirmed by other causes, such as vasculitis, postoperative stroke, cardiogenic cerebral embolism; 2. Patients with cognitive impairment caused by other diseases: Parkinson's disease and Parkinson's syndrome, psychiatric history, Alzheimer's disease, Lewy body dementia and other degenerative cognitive impairment, hydrocephalus, brain tumor, intracranial infection history, epilepsy history, intracranial autoimmune diseases; 3. Patients who use drugs that affect cognitive function during hospitalization: such as cholinesterase inhibitors, etc; 4. Patients with stenosis degree of more than 50% except for the responsible carotid artery and vertebral artery; 5. Patients with physical function defect who can not complete the cognitive examination: such as aphasia, apraxia, audiovisual impairment, etc.; 6. Patients with depression, serious anxiety, drug and alcohol abuse and mental disorders; 7. Patients with severe physical diseases, such as heart, liver and kidney dysfunction; 8. Patients with MRI contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| enlarged perivascular spaces;Montreal cognitive assessment;Mini-Mental State Examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood fat;Blood glucose;Uric acid;C-reactive protein;Homocysteine;Hamilton Depression Scale; | — |
Countries
China
Contacts
Public ContactYu Tu
Zhuhai People's Hospital (Zhuhai Hospital affiliated with Jinan University)
Outcome results
None listed