Type 2 diabetes mellitus complicated with cerebral small vessel disease
Conditions
Interventions
Gold Standard:According to the "Consensus on Diagnosis and Treatment of Cerebrovascular Diseases in China" in 2015, the diagnostic criteria are recommended
1. The clinical manifestation of cerebral s
Index test:The 
of 
FAZ 
and 
blood 
flow 
in 
the 
both 
eyes 
were 
by 
Sponsors
The Second Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The inclusion criteria of normal control group were as follows 1. Subjects with education level of primary school or above; 2. Subjects with corrected visual acuity >= 4.9 (standard logarithmic visual acuity chart); 3. Subjects with diopter less than or equal to ± 3.0d; 4. Subjects with IOP = 4.6 (standard logarithmic visual acuity chart); 5. Subjects with diopter less than or equal to ± 3.0d; 6. Subjects with IOP <= 21mmhg (1mmhg = 0.133kpa) denied history of ocular hypertension; 7. Subjects with no previous history of intraocular surgery, laser and trauma; 8. No obvious abnormality of anterior segment was found in slit lamp examination.
Exclusion criteria
Exclusion criteria: Diabetes or other serious diseases; other causes of small cerebral vessels; other factors affecting cognitive function 1. Acute complications of diabetes mellitus; 2. Severe chronic complications; 3. Identify inflammatory diseases; 4. Autoimmune diseases; 5. History of tumor; 6. History of hereditary cerebrovascular disease; 7. Alzheimer's disease related dementia; 8. History of head trauma or stroke and other neurological diseases; 9. Vitamin B deficiency; 10. History of thyroid dysfunction; 11. History of exposure to poisons; (Note: points 9-11 mainly affect peripheral neuropathy, but have little effect on cerebral small vessel disease) The influencing factors of eye diseases were as follows 12. Diseases with obvious refractive medium turbidity affecting fundus examination and inability to fix vision; 13. Other fundus diseases other than diabetic retinopathy, such as glaucoma (which has been excluded in the inclusion criteria), age-related macular degeneration, high myopia (which has been excluded in the inclusion criteria); 14. Hypertensive retinopathy; 15. Ischemic optic neuropathy; 16. Central serous chorioretinopathy and other retinopathy that may interfere with OCT analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Size of avascular zone in fovea retinae;Blood flow density; | — |
Countries
China
Contacts
Public ContactXiahong Lin
The Second Affiliated Hospital of Fujian Medical University
Outcome results
None listed