acute hypoxic respiratory failure
Conditions
Interventions
experimental group:Extubation followed by immediate noninvasive ventilation
control group:Extubation after successful spontaneous breathing test
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 85 years; 2. Invasive mechanical ventilation >=48 hours.
Exclusion criteria
Exclusion criteria: 1. Women during pregnancy; 2. ARF secondary to status asthmaticus, COPD, and cardiogenic pulmonary edema; 3. PaCO2>50mmHg; 4. Absolute contraindications to noninvasive ventilation (e.g.facial surgery or severe facial trauma, airway, esophagus and stomach surgery, severe neurological injury that fails to protect airway, etc.); 5. presence of tracheotomy; 6. participating in other respiratory related studies; 7. Patients or family members refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the time spent on i-MV;the time spent on ICU LOS; | — |
Secondary
| Measure | Time frame |
|---|---|
| the mortality of ICU;mortality at 28 and 60 days;rate of reintubation;proportion of patients receiving a tracheostomy;Proportion of patients treated with antibiotics for respiratory infection;total days receiving antibiotics;Incidence of delirium during ICU;hospital LOS; | — |
Countries
China
Contacts
Public ContactShen Feng
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed