Labor analgesia
Conditions
Interventions
A:10 ml 0.5 ug / ml dexmedetomidine combined with 0.1% ropivacaine
B:10ml 0.5 ug / ml sufentanil combined with 0.1% ropivacaine
Sponsors
Chengdu Women's and Children's Central Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.1 aged >=18 years old; 1.2 primiparas with single full-term pregnancy (gestational weeks >=37W), vaginal delivery and labor analgesia requirements; 1.3 American Society of anesthesiologists (ASA) grade I ~ II; 1.4 the subjects participated voluntarily and informed consent was signed
Exclusion criteria
Exclusion criteria: 2.1 patients with severe heart, lung, liver, kidney and other organ diseases, hemorrhagic diseases or other system diseases; 2.2 patients with contraindications to epidural analgesia or allergic to local anesthetics to be used; 2.3 the body temperature was higher than 37.5 degree C before analgesia; 2.4 patients with cervical dilatation > 3 cm, non cephalic pregnancy, cesarean section and induced labor; 2.5 known genetic or congenital fetal malformations, fetal growth restriction or oligohydramnios possibly related to placental dysfunction; 2.6 patients with malignant tumor or severe preeclampsia; 2.7 patients with history of cesarean section, lower abdominal surgery or urinary surgery; 2.8 spinal deformity or previous spinal surgery; 2.9 patients with sedative or long-term use of sedative drugs; 2.10 patients with mental history; 2.11 those who are considered unsuitable to participate in the clinical study by the competent physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score;blood pressure;Body temperature, blood pressure, heart rate, mean arterial pressure, VAS score, Ramsay Sedation Scale score and motor nerve block level;The time of analgesic initiation, the first labor process, the second labor process and the total labor process time;Whether there is bleeding during labor and the amount of bleeding, the amount of bleeding in 2 hours and 24 hours after delivery;Total use of analgesics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sex of newborn;Birth weight of newborn;Apgar score at 1 and 5 min after delivery;NBNA in 3-day-old neonates; | — |
Countries
China
Contacts
Public ContactFan Mei
Chengdu Women's and Children's Central Hospital
Outcome results
None listed