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Explore the mechanism of Qigong Pill regulating AdipoR/AMPK pathway to improve oocyte quality in patients with phlegm-dampness PCOS based on network pharmacological analysis

Explore the mechanism of Qigong Pill regulating AdipoR/AMPK pathway to improve oocyte quality in patients with phlegm-dampness PCOS based on network pharmacological

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000038697
Enrollment
Unknown
Registered
2020-09-29
Start date
2020-10-05
Completion date
Unknown
Last updated
2020-12-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PCOS

Interventions

Sponsors

Shandong University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: (1) married women aged between 25 and 40 years; (2) Diagnosed polycystie ovarian syndrome; (3) indications in accordance with IVF; (4) the conditions of reproductive endocrine and vaginal color ultrasound are in accordance with the standard of downregulation; (5) knowingly and agree to participate in the treatment of this study and receive follow-up.

Exclusion criteria

Exclusion criteria: (1) the uterus does not have pregnancy function or severe somatic diseases cannot bear pregnancy; (2) those who use hormone drugs in the past 3 months; (3) suffering from serious cardiovascular and cerebrovascular diseases, such as hypertension, coronary heart disease and other liver and kidney diseases, mental disorders; Patients with acute infection of genitourinary system, sexually transmitted diseases and blood diseases; (4) patients with genetic diseases that are unfertile under the Maternal and Child Health Care Law and are currently unable to undergo preimplantation genetic diagnosis; (5) diseases with similar clinical and endocrine signs caused by other causes, such as ovarian or adrenal tumors, adrenal cortical hyperplasia, etc.; (6) those who are exposed to teratogenic radiation, poisons or drugs and are in the active stage; (7) people with serious bad habits such as drug abuse.

Design outcomes

Primary

MeasureTime frame
APN;AdipoR1;Adipor2;AMPK;p-ampk;ACC;CPT;the rate of high quality oocyte;the rate of high quality embryo;p-ACC;

Countries

China

Contacts

Public ContactShuang-Qian Dong, Jian-Wei Zhang

Shandong University of Traditional Chinese Medicine

dongshuangqian@sina.com+86 15662001710

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026