Gastroscopy
Conditions
Interventions
1:remimazolam + propofol
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 70 years old; 2) patients who receive routine gastroscopy; 3) ASA score is I or II; 4) 18 kg/m2 < BMI < 30kg/ m2; 5) the operation time of gastroscope is expected to be no longer than that of 30min; 6) No sleep disorder; 7) clearly understand and voluntarily participate in the study, and the informed consent form shall be signed by him.
Exclusion criteria
Exclusion criteria: Patients with any of the following items cannot be enrolled in this study: 1) complex endoscopic techniques (such as cholangiopancreatography, endoscopic ultrasonography, endoscopic mucosal resection, endoscopic submucosal dissection, transoral endoscopic myotomy, etc.); 2) patients who are going to undergo endotracheal intubation; 3) patients with respiratory tract management difficulties (modified Mahalanobis score as IV); 4) anemia or thrombocytopenia, Hb =2.5 ULN,TBIL >=1.5 ULN; 6) the renal function is abnormal and the serum creatinine is higher than the upper limit of the normal value; 7) there is a history of drug use and / or alcohol abuse in the 2 years before the start of the screening period, that is, drinking more than 2 units of alcohol per day on average; (1 unit = 360 mL beer or 45 mL spirits with 40% alcohol or 150 mL wine). 8) hypertensive patients whose blood pressure was not satisfactorily controlled by antihypertensive drugs (sitting systolic blood pressure >=160mmHg, and / or screening diastolic blood pressure >=100mmHg); 9) the systolic blood pressure of sitting position during the screening period is less than 90 mmHg; 10) pregnant or lactating women; 11) allergic or taboo to benzodiazepines, opioids, propofol, lidocaine and their drug components; 12) participated in clinical trials of other drugs as subjects in the past 3 months; 13) the researchers do not think it is appropriate for patients to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate;Effect on sleep status;Gastroscopy physician's satisfaction with the effect of anesthesia;Body movement score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation induction time;Sedation and awakening time;Incidence of hypotension;Incidence of respiratory depression during sedation; | — |
Countries
China
Contacts
Public ContactYonghao Yu
Department of Anesthesiology, General Hospital of Tianjin Medical University
Outcome results
None listed