middle cerebral artery stenosis/occlusion
Conditions
Interventions
EC-IC bypass:low-flow STA-MCA bypass
PTAS:PTAS
Sponsors
3rd Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. In the last 6 months, under standard antiplatelet or anticoagulation treatment, symptoms of cerebral ischemia still occur, including transient melancholia, TIA attacks, and small strokes (persistent neurological impairment with NIHSS = 50%, < 100% (determined by WAIDS method); 6. SPECT or CTP showed that the MTT ratio of the ipsilateral-to-contralateral frontal posterior inferior gyrus is greater than 1.13 (refer to the ratio of the affected and contralateral Oxygen extraction fraction in the COSS enrollment criteria); 7. DSA showed the presence of the superficial temporal artery on the affected side.
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhage or hemorrhagic cerebral infarction occurred in the past 6 months, or a large area of cerebral infarction with a diameter of more than 5 mm in a stenosis-related area, or severe stroke (NIHSS score >= 9 points); 2. Intracranial arterial stenosis for special reasons: for example, confirmed moyamoya disease, moyamoya syndrome, cerebral arteritis (infectious arteritis, systemic vasculitis), muscular fiber dysplasia, cerebral artery window deformity, radiation injury, arterial dissection Patient 3. accompanied by intracranial tumors, aneurysms and cerebral arteriovenous malformations; 4. Patients cannot receive aspirin, clopidogrel, and are allergic to heparin or iodine-containing contrast agents; 5. Renal insufficiency, or combined with severe heart, lung, liver and other organ dysfunction; 6. Positive pregnancy test for women of childbearing age; 7. hemoglobin 1.5; 9. non-iatrogenic uncorrectable bleeding tendency; 10. A history of major surgery within 30 days; 11. Poor general condition, intolerance of general anesthesia surgery, or 12. life expectancy < 5 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transient ischemic attack;Infarction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral hemorrhage;Cerebral blood perfusion;STA diameter;Diameter in stenosis site of MCA;Hospital costs; | — |
Countries
China
Contacts
Public ContactChen Chuan
3rd Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed