Knee Osteoarthritis
Conditions
Interventions
experimental group:PRP is injected into the joint cavity once a week for 4 weeks on the basis of health education and conventional quadriceps training methods
control group:Sodium hyaluronate is injected into the joint cavity once a week for 4 weeks on the basis of health education and routine quadriceps training
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for knee osteoarthritisGuidelines for the Diagnosis and Treatment of Osteoarthritis, 2018 edition, Joint Surgery Group, Osteoscience Branch, Chinese Medical Association; 2. Kellgren-Lawrence grade II - IV; 3. Between the ages of 40 and 75; 4. BMI is less than 30; 5. Knee osteoarthritis has not been treated in any way in recent 3 months 6. Good compliance, willing to cooperate with the study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Autoimmune arthropathy; 2. Patients with pain in the acute stage of knee osteoarthritis; 3. Patients with bleeding tendency or coagulation dysfunction; 4. Infection, surgery and radiation treatment of the knee within three months; 5. Injected glucocorticoid or sodium hyaluronate within 3 months; Infection of the skin in the injection area; 6. Pregnant women or lactating women; 7. imaging examination before treatment KL class reach IV; 8. Suffering from severe organ failure, severe cardiovascular and cerebrovascular diseases, blood diseases and infectious diseases; 9. Other study participants who are participating in and influencing the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale, VAS;Western Ontario and McMaster University Osteoarthritis Score, WOMC; | — |
Secondary
| Measure | Time frame |
|---|---|
| interleukin-6;ADL score;erythrocyte sedimentation rate;C-reactive protein;x-ray examination; | — |
Countries
China
Contacts
Public ContactLin Ruizhu
General Hospital of Ningxia Medical University
Outcome results
None listed