polycystic ovarian syndrome
Conditions
Interventions
experimental group:bromocriptine mesylate and letrozole
control group: letrozole
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 38 Years
Inclusion criteria
Inclusion criteria: (1) Younger than 38 years old; (2) Diagnosed as polycystic ovary syndrome and infertility for more than 1 year; (3) Being treated with oral contraceptives for more than 3 months, or LH <10 IU/L and testosterone value normal within 3 months; (4) No hydrosalpinx, at least one fallopian tube is unobstructed; (5) Body mass index (weight kg/height cm2) <25 kg/m2; (6) Husband's semen examination is normal; (7) Willing to follow the research plan and be able to complete scheduled follow-up.
Exclusion criteria
Exclusion criteria: (1) Any serious cardiovascular, lung, liver and kidney disease; (2) Alcoholism, drug addiction or uncured venereal disease; (3) Pregnancy before admission; (4) Organic uterine diseases such as uterine malformations, adenomyosis, endometrial polyps, etc.; (5) Be allergic to study drugs; (6) History of severe OHSS; (7) Currently receiving neuropsychiatric drug treatment, or receiving any drug that may affect normal reproductive function (such as neuroleptics, dopamine receptor antagonists, etc.); (8) Any abnormal situation determined by the researcher that may affect the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| ovulation rate;follicular number;endometrial thickness;gonadal hormone concentrations; | — |
Countries
China
Contacts
Public ContactMeiqing Xie
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed