Painless gastrointestinal endoscopy
Conditions
Interventions
Group E0:Direct injection of propofol 3µg/mL via TCI
Group E1:After administering 0.125 mg/kg of dextro-ketamine for 1 min, inject propofol 3 µg/mL via TCI
Group E2:After administering 0.25mg/kg of dextro-ketamine for 1 min, inject propofol 3 µg/mL via TCI
Group E3:After administering 0.5mg/kg of dextro-ketamine for 1 min, inject propofol 3 µg/mL via TCI
Sponsors
Nanchong Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-II; 2. Aged 18 to 65 years old; 3. BMI 20 to 28; 4. Adult patients who intend to undergo painless electronic gastroscopy; 5. Have an education level of junior high school or above to complete the neuropsychological test.
Exclusion criteria
Exclusion criteria: 1. History of drug abuse; 2. Patients with hypertension 3. Patients with elevated intracranial pressure and intraocular pressure; 4. Patients with upper gastrointestinal bleeding; 5. Patients with apnea syndrome; 6. Patients with diabetes history; 7. Patients with severe respiratory and cardiovascular system history; 8. Patients with neurological or mental illnesses or previous cognitive impairment; 9. Pregnancy; 10. Patients with impaired liver and kidney function; 11. Patients who are known to be allergic to propofol, etc. and who are expected to have difficulty in intubating the trachea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Aldrete score;VAS pain score;MMSE;Inducing dose of propofol;Supplemental dose of propofol;Total amount of propofol;Rate of body movement;Cough incidence;Gastroscopy time;Wake up time; | — |
Countries
China
Contacts
Public ContactWang Han
Nanchong Central Hospital
Outcome results
None listed