Lung cancer
Conditions
Interventions
Sponsors
Dongfang Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Aged >=18 years old; (2) Non-small cell lung cancer diagnosed by cytology or histopathology; (3) According to the eighth edition of the TNM staging system for lung cancer published by the International Association for the Study of Lung Cancer (IASLC), it is classified as stage IIIb or stage IV; (4) There is at least one cryoablation lesion with a diameter of 3cm3 months; (7) No history of combined immune-related diseases or other tumors. (8) Volunteer to participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Neutrophil count10x10^9/L, platelet2.5 times the upper limit of the normal value in the absence of liver metastasis, or 5 times the upper limit of the reference range of normal value in the case of liver metastasis; (7) Malignant pleural effusion, pericardial effusion or abdominal effusion that is difficult to control; (8) Pregnant or lactating women; (9) HBV or HCV antibody positive; (10) HIV antibody positive, or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TGF-beta 1 content;Treg content;CD4+T content;Treg/CD4+T; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of adverse reactions in patients with different cold ablation ranges;Overall survival, postoperative survival, and progression-free survival of patients with different ranges of cold ablation;Quality of life of patients with different cold ablation ranges; | — |
Countries
China
Contacts
Public ContactLi Quanwang
Dongfang Hospital Beijing University of Chinese Medicine
Outcome results
None listed