Neuroendocrine axis-biological clock system and NDRG2-glutamate transport system participate in functional gastrointestinal disease/gastrointestinal motility disorders and stress-related visceral hypersensitivity

CTX preconditioning mediated NDRG2 involvement in chronic visceral pain - central sensitization through EAAT2 and its mechanism

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000038551

Enrollment

Unknown

Registered

2020-09-23

Start date

2019-01-01

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Functional Gastrointestinal Disease/Gastrointestinal Motility Disorder

Interventions

control group:conventional therapy

experimental group:Fluoxetine combined conventional treatment

Eligibility

Sex/Gender

All

Age

22 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1) Patients with digestive psychosomatic diseases included according to Rome IV criteria; 2) Meet the requirements and obtain informed consent; 3) The relevant information is complete, including age, gender, and unique and traceable serial numbers, etc.

Exclusion criteria

Exclusion criteria: 1) Patients with diseases such as hyperthyroidism that significantly change the indicators of the brain-gut axis; 2) Patients with known gastrointestinal tumors and severe gastrointestinal ulcers; 3) Samples that do not meet the requirements of sample collection and processing; 4) The test result is missing the test result of the test agent (or comparison method); 5) During the test, there are cases where the test results are recorded incorrectly and the source cannot be traced.

Design outcomes

Primary

Measure	Time frame
Cortisol;Adrenocorticotropic hormone;blood sugar;Thyroid function;	—

Countries

China

Contacts

Public ContactMin Yang

Army Medical Center of PLA, Daping Hospital, Army Medical University

yangmindoctor@126.com+86 18983098877

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026