polycystic ovarian syndrome
Conditions
Interventions
Control group:Metformin
Sponsors
Shanghai Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 40 years; 2. Confirmed diagnosis of PCOS according to the Rotterdam 2003 criteria (2 of 3): (1) Oligo-ovulation or anovulation; (2) Clinical and/or biochemical signs of hyperandrogenism; (3) PCOs and exclusion of other aetiologies (congenital adrenal hyperplasia, androgen-secreting tumours and Cushing's syndrome); 3. Confirmed diagnosis of insulin resistance; 4. Confirmed diagnosis of ovulatorydysfunction; 5. join voluntarily and sign an informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with known severe organ dysfunction or mental illness; 2. Use of hormonal drugs or other medications including Chinese herbal prescriptions in the past 3 months; 3. Pregnancy, postabortion or postpartum within the past 6 weeks; 4. Breastfeeding within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ovulation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Luteinising hormone (LH);Follicle-stimulating hormone (FSH);Total testosterone (T);Fasting glucose;Fasting insulin concentrations;cholesterol;triglycerides;high-density lipoprotein cholesterol (HDL-C);low-density lipoprotein cholesterol (LDL-C);Interleukin 1 beta;Interleukin-2 receptor;Interleukin-6;Interleukin-8;Interleukin-10;Tumor necrosis factor a;Ovarian volume;Number of small follicles;Endometrial thickness; | — |
Countries
China
Contacts
Public ContactNi Xiaorong
Shanghai Traditional Chinese Medicine Hospital, Shanghai, China
Outcome results
None listed