Noninvasive diagnosis and prognosis of hemodialysis induced myocardial injury by new echocardiography techniques

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000038479

Enrollment

Unknown

Registered

2020-09-23

Start date

2020-10-01

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Maintenance hemodialysis patients

Interventions

Gold Standard:1. Myocardial injury markers

2. Prognosis of cardiovascular events.

Index test:HIMI&#32

diagnostic&#32

model

HIMI&#32

prediction&#32

model.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria of case group 1. Those patients with long-term (>= 6 months) hemodialysis in the blood purification center of our hospital; 2. Age: 18-70 years, male: female: about 1:1; 3. Patients with clear ultrasound images of body surface; 4. Patients who can complete dialysis and follow-up according to dialysis plan. The inclusion criteria of the control group: healthy people matched with gender and age.

Exclusion criteria

Exclusion criteria: Exclusion criteria for case group: 1 1. Patients with acute myocardial infarction and major vessel surgery within 3 months; 2. Patients with acute chest pain lasting more than 20 minutes within 2 weeks; 3. Patients with intramuscular injection and trauma history within two weeks; 4. History of autoimmune disease, rheumatic heart disease, thyroid disease, epilepsy or malignant tumor; 5. Patients with arrhythmia, including persistent atrial fibrillation, CLBBB, frequent premature beats, etc. The exclusion criteria of the control group were as follows 1. Patients with previous history of coronary heart disease, including angina pectoris, myocardial infarction, after coronary artery bypass grafting or coronary stent implantation; 2. Patients with large vessel level or intracardiac shunt; 3. Patients with heart valve disease, cardiomyopathy or pericardial disease; 4. Patients with a history of heart failure; 5. Patients with arrhythmia, including persistent atrial fibrillation, CLBBB, frequent premature beat, etc; 6. Patients with unclear ultrasound images.

Design outcomes

Primary

Measure	Time frame
hs-cTnT;??CRP;IL-6;strain;SEN, SPE, ACC, AUC of ROC, PPV, NPV;	—

Countries

China

Contacts

Public ContactSun Minmin

Zhongshan Hospital Affiliated to Fudan University

sun.minmin@zs-hospital.sh.cn+86 13817826956

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026