Colorectal cancer
Conditions
Interventions
Gold Standard:Clinical outcome
on 
endogenous 
biomarkers 
by 
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as colon cancer or recurrent colorectal cancer by pathological biopsy, cytology and imaging examination (diagnosis by two experienced imaging doctors). 2. Patients with at least one measurable lesion on two-dimensional imaging. 3. Patients with colorectal cancer who are willing to accept capecitabine based chemotherapy and are willing to participate in this study. 4. Patients with KPS >= 70 in physical condition assessment (can take care of themselves, but can't maintain normal life and work) 5. Patients whose survival time is expected to be more than 3 months. 6. Patients with age >= 18 years old, both male and female. 7. Patients with chemotherapy indications, including those with normal functions of organs such as heart, liver and kidney, and bone marrow without hematopoietic dysfunction. 8. Patients with complete physical examination and laboratory examination should be evaluated before treatment.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating patients. 2. Patients with other malignant tumors at the same time. 3. Patients with brain metastases accompanied with neurological symptoms or poor control. 4. The patients who are allergic to fluorouracil drugs or have serious metabolisms. 5. Patients with severe infection. 6. Patients with dysphagia or active peptic ulcer, bleeding or digestive tract obstruction. 7. Patients with severe heart, liver and kidney diseases such as angina pectoris, myocardial infarction, renal failure, uremia and liver failure. 8. Patients considered unsuitable for inclusion in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SEN, SPE, ACC, AUC of ROC, PPV, NPV; | — |
Countries
China
Contacts
Public ContactGao Shouhong
Shanghai Changzheng Hospital
Outcome results
None listed