Pediatric diseases
Conditions
Interventions
Mothers and their offsprings in low-altitude areas (Main cohort and sub-cohort), Mothers and their offsprings in high-altitude areas ( Supplementary cohort), Mothers and their offsprings who are ethni
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 49 Years
Inclusion criteria
Inclusion criteria: 1. Main cohort: (1) Subjects planned to give birth in the hospital where they registered the account; (2) Subjects lived in the municipal district where the survey hospital was located, and had no relocation plan in six years; (3) Subjects had normal reading and communication ability; (4) Subjects were willing to sign the informed consent and cooperate with the whole follow-up survey; (5) Subjects can use wechat and will not change mobile phone number in six years. 2. Supplementary cohort (1) High-altitude hypoxic exposure child cohort 1) Subjects lived in the area with altitude higher than 2500 meters; (2) Ethnic minority child cohort 1) Zang, Mongolia, Tu, Sala, Qiang, Yi, Hui, Dongxiang, Baoan, Yugu, Miao, Buyi, Dong and other ethnic minorities; 2) The place of residence was consistent with the place of birth; 3) All direct relatives within three generations had same ethnicity; 3. Sub-cohort (1) Subjects with 6-12 weeks of gestation had Chinese nationality; (2) Both natural conception and assisted reproductive technology were acceptable; (3) Subjects registered account, selected the child healthcare service at our designated clinical centers and had no plan to relocate to another province in two years.
Exclusion criteria
Exclusion criteria: 1. Main cohort (1) Subjects or her guardian had inadequate reading ability; (2) Subjects had inadequate communication ability, cognitive impairment or mental diseases. 2. Sub-cohort (1) Subjects had notifiable infectious diseases including hepatitis B, syphilis and HIV; (2) Subjects had severe mental diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Growth and development of children (Main cohort/Supplementary cohort): height, weight, head circumference, language ability, motor skills, cognitive ability, etc.;High-incidence and high-risk pediatric diseases (Main cohort/Supplementary cohort): malnutrition, anemia, retardation of growth, obesity, allergic diseases, asthma, autism, language disorders, congenital malformations, etc.;Growth and development of children (Sub-cohort): height, weight, head circumference, language ability, motor skills, cognitive ability, etc.;High-incidence and high-risk pediatric diseases (Sub-cohort): malnutrition, anemia, retardation of growth, obesity, allergic diseases, asthma, autism, language disorders, congenital malformations, etc.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy outcome (Main cohort/Supplementary cohort): miscarriage, stillbirth, intrauterine fetal demise, preterm birth, low birth weight, intrauterine growth restriction, etc.;Pregnancy complications (Main cohort/Supplementary cohort): gestational hypertension, preeclampsia, eclampsia, gestational anemia, premature rupture of membranes, etc.;Rare diseases in children (Main cohort/Supplementary cohort): phenylketonuria, glucose-6-phosphate dehydrogenase deficiency, congenital scoliosis, congenital deafness, retinoblastoma, etc.;Pregnancy outcome (Sub-cohort): miscarriage, stillbirth, intrauterine fetal demise, preterm birth, low birth weight, intrauterine growth restriction, etc.;Pregnancy complications (Sub-cohort): gestational hypertension, preeclampsia, eclampsia, gestational anemia, premature rupture of membranes, etc.;Rare diseases in children (Sub-cohort): phenylketonuria, glucose-6-phosphate dehydrogenase deficiency, congenital scoliosis, congenital deafness, retinoblastoma, etc.; | — |
Countries
China
Contacts
Public ContactZhao Xiaodong/Li Yan
Children's Hospital of Chongqing Medical University
Outcome results
None listed