Ulcerative colitis
Conditions
Interventions
control group:Mesalazine alone
trial group:Mesalazine and ursodeoxycholic acid soft capsule
Patients with mild bile reflux gastritis: ursodeoxycholic acid soft capsule
Healthy control group:Nil
Sponsors
The 900th Hospital of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. For patients aged 18-75 years, there is no limit to gender, and the range of intestinal lesions is not limited; 2. According to the consensus on the diagnosis and treatment of inflammatory bowel disease (Guangzhou, 2012) formulated by the society of inflammatory bowel disease, Chinese society of Gastroenterology, Chinese Medical Association, and the improved truelove and witts disease severity classification for severity, combined with endoscopic examination, patients with mild and moderate severity were selected; 3. Patients with underlying diseases should maintain the stability of relevant drug dosage and category 2 weeks before the baseline period of this study, and antibiotics or probiotics should not be used 3 months before the baseline period.
Exclusion criteria
Exclusion criteria: 1. Patients with more serious heart, liver, kidney and other organs and blood, immune system or endocrine system lesions; 2. Patients with active upper gastrointestinal ulcer, ischemic bowel disease, intestinal infectious disease, radiation enteritis, intestinal lymphoma, drug-related intestinal disease and transient colitis of unknown origin; 3. Patients who have been diagnosed with digestive tract tumor and have a history of intestinal resection; 4. Women during pregnancy or lactation; 5. Patients allergic to salicylic acid and other drugs; 6. Patients who used antibiotics or probiotics 3 months before taking feces for microbiological examination; 7. Patients with diabetes, hypertension and other basic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora; | — |
Countries
China
Contacts
Public ContactWang Wen
The 900th Hospital of PLA
Outcome results
None listed