Traumatic brain injury
Conditions
Interventions
conventional mechanical ventilation group:Tidal volume 10ml/kg corrected body weight, with 0 cmH2O PEEP, and no recruitment maneuvers.
low tidal volume+5cmH2O PEEP group:Tidal volume 8ml/kg corrected body weight, with continuous 5cmH2O PEEP during operation, and no recruitment maneuvers.
low tidal volume+5cmH2O PEEP+recruitment maneuvers group:Tidal volume 8ml/kg corrected body weight, with continuous 5cmH2O PEEP during operation, and recruitment maneuvers were implemented before open
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. The patient was diagnosed with traumatic brain injury and underwent emergency evacuation of hematoma in Subei people's hospital. 2. The patients were of either gender, aged 18-65 years, 3. ASA grade I - II, 4. Body mass index 18.5 ~ 29.9kg/m2.
Exclusion criteria
Exclusion criteria: 1. People with mental or cognitive impairment, or other neurological dysfunction before operation (inflammatory brain diseases, myelitis, epilepsy, dementia, cerebral vascular malformations, etc.); 2. Patients with severe respiratory diseases before operation (lung infection, pneumoconiosis, interstitial lung disease, chronic bronchitis, chronic obstructive pulmonary diseases, asthma, etc.); 3. Patients with severe cardiovascular diseases (rheumatic heart disease, valve heart disease, pericarditis, pulmonary heart disease, myocarditis, etc.); 4. Patients with severe liver and kidney dysfunction (liver cirrhosis, drug-induced liver injury, chronic renal failure, hypertensive nephropathy, etc.); 5. Patients with stroke, cerebral hemorrhage, myocardial infarction, trauma, major surgery, etc. over the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2;PaCO2;Cdyn;Ppeak;Pplat;HR;MAP;CPIS;postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| GFAP;UCHL1;ONSD;postoperative neurologic complications;postoperative mechanical ventilation time;GOSE;length of stay; | — |
Countries
China
Contacts
Public ContactJu Gao
Northern Jiangsu People's Hospital
Outcome results
None listed