Mild Cognitive Dysfunction
Conditions
Interventions
1:Sevoflurane and propofol
2: Sevoflurane
3:propofol
Sponsors
Tianjin Third Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. ASA grade I ~ III in elderly patients undergoing elective lumbar surgery; 2. The estimated operation time is 2 hours to 4 hours; 3. The patient's age is more than or equal to 65 years old; 4. The hospital stay of the patients should not be less than 3 days (operation day and 2 days after operation); 5. Patients without severe hearing and visual impairment have the ability to read and complete neurobehavioral tests.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of dementia, psychiatry or any central nervous system disease; 2. Patients with severe cerebrovascular disease or history of cerebrovascular disease with cognitive dysfunction; 3. Patients who have recently taken sedatives or antidepressants; 4. Alcoholism or drug dependence; 5. Patients with severe hepatic and renal insufficiency; 6. Patients who have participated in this trial in the past; 7. Patients who are considered unsuitable for clinical trial by clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral tissue oxygen saturation, SctO 2;Cognitive condition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Long term prognosis; | — |
Countries
China
Contacts
Public ContactWang Haiyun
Tianjin Third Central Hospital
Outcome results
None listed